Cannabinoids in nature and medicine

Didier M. Lambert (ed.)

Originally a special issue of Chemistry & Biodiversity, the first part of this volume focuses on the plant Cannabis sativa, its active ingredients, and the discovery of cannabinoid receptors as well as the therapeutic applications of activating, or blocking, the receptors. Following an overview of the plant, its medicinal uses, and its preparations, further chapters cover biosynthetic pathways, pharmacological properties, cannabis-based medicine, toxicology, cannabis prohibition and clinical situations where blocking the cannabinoid receptors might be beneficial. The second part covers the journey from humans to plants, analyzing anandamide, as well as other endocannabinoids and endocannabinoid congeners, biosynthetic pathways, current knowledge of FAAH-1, FAAH-2, monoglyceride lipase and NAAA, concluding with new areas of research.

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[目次]

  • Introduction The Endocannabinoid System at a Glance ( B. Bosier and D. M. Lambert ). Part 1 The Phytocannabinoids: The Long Journey from the Plant to the Humans. History of Cannabis and Its Preparations in Saga, Science and Sobriquet ( E. B. Russo ). Phytocannabinoids in Cannabis sativa : Recent Studies of Biosynthetic Enzymes ( F. Taura, S. Sirikantaramas, Y. Shoyama, Y. Shoyama and S. Morimoto ). On the Pharmacological Properties of DELTA 9 -Tetrahydro-cannabinol (THC) ( B. Costa ). Cannabidol - Recent Advances ( R. Mechoulant, M. Peters, E. Murillo-Rodriquez and L. O. Hanus ) From Active Ingredients to the Discovery of the Targets: The Cannabinoid Receptors ( K. Mackie ). Medicinal Chemistry Endeavors around the Phyto-cannabinoids ( E. Stern and D. M. Lambert ). Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials at Sativex (R), a Cannabis-Based Medicine ( E. B. Russo, G. W. Guy and P. J. Robson ). The Toxicology of Cannabis and Cannabis Prohibition ( F. Grotenhermen ). Human Cannabinoid Pharmacokinetics ( M. A. Huestis ). Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises ( G. G. Muccioli ). Part 2 The Endocannabinoid System: The Short Journey from the Humans to the Plants. Discovery and Isolation of Anandamide and Other Endocannabinoids ( L. O. Hamus ). Biosynthetic Pathways of the Endocannabinoid Anandamide ( Y. Okamoto, J. Wang, J. Morishita and N. Ueda ). The Multiple Pathways of Endocannabinoid Metabolism: A Zoom Out ( S. Vandevoorde and D. M. Lambert ). Fatty Acid Amide Hydrolase: From Characterization to Therapeutics ( G. Labar and C. Michaux ). Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol ( S. M. Saario and J. T. Laitinen ). The N -Acylethanolamine-Hydrolyzing and Acid Amidase (NAAA) ( K. Tsuboi, N. Takezaki and N. Ueda ). Genetic Polymorphisms of the Endocannabinoid System ( A. G. Norrod and R. A. Puffenbarger ). The N -Acylethanolamine-Mediated Regulatory Pathway in Plants ( A. Kilaru, E. B. Blacafor, B. J. Venables, S. Tripathy, K. S. Mysore and K. D. Chapman ). Index.

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この本の情報

書名 Cannabinoids in nature and medicine
著作者等 Lambert, Didier M
Lambert Didier M.
出版元 Wiley-VCH
刊行年月 c2009
ページ数 xiii, 416 p.
大きさ 25 cm
ISBN 9783906390567
NCID BB00268966
※クリックでCiNii Booksを表示
言語 英語
出版国 ドイツ
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