Ion channels of excitable membranes

Bertil Hille

This fully revised and expanded third edition of "Ionic Channels of Excitable Membranes" describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signalling, structural biology, and molecular biology and genomics. The text begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. It is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses.

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[目次]

  • PART I Classical biophysics of the squid giant axon The superfamily of voltage-gated channels Voltage-gated calcium channels Potassium channels and chloride channels Ligand-gated channels of fast chemical synapses Modulation, slow synaptic action, and second messengers Sensory transduction and excitable cells Calcium dynamics, epithelial transport, and intercellular coupling PART II Elementary properties of ions in solution Elementary properties of pores Counting channels Structure of channel proteins Selective permeability: Independence Selective permeability: Saturation and binding Classical mechanisms of block Structure-function studies of permeation and block Gating mechanisms: Kinetic thinking Gating: Voltage sensing and inactivation Modification of gating in voltage-sensitive channels Cell biology and channels Evolution and origins

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この本の情報

書名 Ion channels of excitable membranes
著作者等 Hille, Bertil
書名別名 Ionic channels of excitable membranes
出版元 Sinauer Associates
刊行年月 c2001
版表示 3rd ed
ページ数 xviii, 814 p., [8] p. of plates
大きさ 24 cm
ISBN 9780878933211
NCID BA53175902
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言語 英語
出版国 アメリカ合衆国
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