Protein NMR spectroscopy : principles and practice

John Cavanagh ... [et al.]

"Protein NMR Spectroscopy" combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution. Beginning with simple theoretical models and experimental techniques, "Protein NMR Spectroscopy" develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments. Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book which was published in 1996. The second edition includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced. "Protein NMR Spectroscopy" is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or who wish to understand the latest developments in this field. It provides an understanding of the theoretical principles important for biological NMR spectroscopy. It demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments. It allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics. It includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods.

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[目次]

  • Preliminary Table of Contents 1. Classical NMR Spectroscopy 2. Theoretical Description of NMR Spectroscopy 3. Experimental Aspects of NMR Spectroscopy 4. Multi-Dimensional NMR Spectroscopy 5. Relaxation and Dynamic Processes 6. Experimental 1H NMR Methods 7. Heteronuclear NMR Experiments 8. Experimental NMR Relaxation Methods 9. Larger Proteins and Molecular Interactions 10. Sequential Assignment, Structure Determination and Other Applications

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この本の情報

書名 Protein NMR spectroscopy : principles and practice
著作者等 Cavanagh, John
Palmer III, Arthur G.
Rance, Mark
Skelton, Nicholas J.
Fairbrother, Wayne J.
出版元 Elsevier Academic Press
刊行年月 c2007
版表示 2nd ed
ページ数 xxv, 885 p.
大きさ 24 cm
ISBN 012164491X
NCID BA79479990
※クリックでCiNii Booksを表示
言語 英語
出版国 オランダ
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