Basic Concept of Development and Practical Application of Animal Models for Human Diseases.- Humanized SCID Mouse Models for Biomedical Research.- NOD/Shi-scid IL2r?null (NOG) Mice More Appropriate for Humanized Mouse Models.- Humanizing Bone Marrow in Immune-Deficient Mice.- The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2r?null Mice.- Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System.- Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development.- Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice.- Humanized Mice for Human Retrovirus Infection.- Functional and Phenotypic Characterization of the Humanized BLT Mouse Model.- Novel Metastasis Models of Human Cancer in NOG Mice.- In Vivo Imaging in Humanized Mice.