The origins of evolutionary innovations : a theory of transformative change in living systems

Andreas Wagner

The history of life is a nearly four billion year old story of transformative change. This change ranges from dramatic macroscopic innovations such as the evolution of wings or eyes, to a myriad of molecular changes that form the basis of macroscopic innovations. We are familiar with many examples of innovations (qualitatively new phenotypes that provide a critical benefit) but have no systematic understanding of the principles that allow organisms to innovate. This book proposes several such principles as the basis of a theory of innovation, integrating recent knowledge about complex molecular phenotypes with more traditional Darwinian thinking. Central to the book are genotype networks: vast sets of connected genotypes that exist in metabolism and regulatory circuitry, as well as in protein and RNA molecules. The theory can successfully unify innovations that occur at different levels of organization. It captures known features of biological innovation, including the fact that many innovations occur multiple times independently, and that they combine existing parts of a system to new purposes. It also argues that environmental change is important to create biological systems that are both complex and robust, and shows how such robustness can facilitate innovation. Beyond that, the theory can reconcile neutralism and selectionism, as well as explain the role of phenotypic plasticity, gene duplication, recombination, and cryptic variation in innovation. Finally, its principles can be applied to technological innovation, and thus open to human engineering endeavours the powerful principles that have allowed life's spectacular success.

「Nielsen BookData」より

The history of life is a nearly four billion year old story of transformative change. This change ranges from dramatic macroscopic innovations such as the evolution of wings or eyes, to a myriad of molecular changes that form the basis of macroscopic innovations. We are familiar with many examples of innovations (qualitatively new phenotypes that provide a critical benefit) but have no systematic understanding of the principles that allow organisms to innovate. This book proposes several such principles as the basis of a theory of innovation, integrating recent knowledge about complex molecular phenotypes with more traditional Darwinian thinking. Central to the book are genotype networks: vast sets of connected genotypes that exist in metabolism and regulatory circuitry, as well as in protein and RNA molecules. The theory can successfully unify innovations that occur at different levels of organization. It captures known features of biological innovation, including the fact that many innovations occur multiple times independently, and that they combine existing parts of a system to new purposes. It also argues that environmental change is important to create biological systems that are both complex and robust, and shows how such robustness can facilitate innovation. Beyond that, the theory can reconcile neutralism and selectionism, as well as explain the role of phenotypic plasticity, gene duplication, recombination, and cryptic variation in innovation. Finally, its principles can be applied to technological innovation, and thus open to human engineering endeavours the powerful principles that have allowed life's spectacular success.

「Nielsen BookData」より

[目次]

  • 1. Introduction
  • 2. Metabolic innovation
  • 3. Innovation through regulation
  • 4. Novel molecules
  • 5. The origins of evolutionary innovation
  • 6. Genotype networks, self-organization, and natural selection
  • 7. A synthesis of neutralism and selectionism
  • 8. The role of robustness for innovation
  • 9. Gene duplications and innovation
  • 10. The role of recombination
  • 11. Environmental change in adaptation and innovation
  • 12. Evolutionary constraints and genotype spaces
  • 13. Phenotypic plasticity and innovation
  • 14. Towards continuous genotype spaces
  • 15. Evolvable technology and innovation
  • 16. Summary and outlook
  • Bibliography
  • Index

「Nielsen BookData」より

[目次]

  • 1. Introduction
  • 2. Metabolic innovation
  • 3. Innovation through regulation
  • 4. Novel molecules
  • 5. The origins of evolutionary innovation
  • 6. Genotype networks, self-organization, and natural selection
  • 7. A synthesis of neutralism and selectionism
  • 8. The role of robustness for innovation
  • 9. Gene duplications and innovation
  • 10. The role of recombination
  • 11. Environmental change in adaptation and innovation
  • 12. Evolutionary constraints and genotype spaces
  • 13. Phenotypic plasticity and innovation
  • 14. Towards continuous genotype spaces
  • 15. Evolvable technology and innovation
  • 16. Summary and outlook
  • Bibliography
  • Index

「Nielsen BookData」より

この本の情報

書名 The origins of evolutionary innovations : a theory of transformative change in living systems
著作者等 Wagner, Andreas
シリーズ名 Oxford biology
出版元 Oxford University Press
刊行年月 2011
ページ数 ix, 253 p.
大きさ 26 cm
ISBN 9780199692590
9780199692606
NCID BB1407862X
※クリックでCiNii Booksを表示
言語 英語
出版国 イギリス
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